Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase

Trioxacarcins (TXNs) are highly oxygenated, polycyclic aromatic natural products with remarkable biological activity and structural complexity. Evidence from (13)C-labelled precursor feeding studies demonstrated that the scaffold was biosynthesized from one unit of l-isoleucine and nine units of mal...

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Detalles Bibliográficos
Autores principales: Zhang, Mei, Hou, Xian-Feng, Qi, Li-Hua, Yin, Yue, Li, Qing, Pan, Hai-Xue, Chen, Xin-Ya, Tang, Gong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659172/
https://www.ncbi.nlm.nih.gov/pubmed/29511509
http://dx.doi.org/10.1039/c5sc00116a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659172/
https://www.ncbi.nlm.nih.gov/pubmed/29511509
http://dx.doi.org/10.1039/c5sc00116a

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