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Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase
Trioxacarcins (TXNs) are highly oxygenated, polycyclic aromatic natural products with remarkable biological activity and structural complexity. Evidence from (13)C-labelled precursor feeding studies demonstrated that the scaffold was biosynthesized from one unit of l-isoleucine and nine units of mal...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659172/ https://www.ncbi.nlm.nih.gov/pubmed/29511509 http://dx.doi.org/10.1039/c5sc00116a |