Enantioselective synthesis of bicyclo[3.n.1]alkanes by chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations

2,2-Disubstituted cyclic 1,3-diketones containing a tethered electron-deficient alkene undergo chiral phosphoric acid-catalyzed desymmetrizing Michael cyclizations to give bridged bicyclic products in high enantioselectivities. Both bicyclo[3.2.1]octanes and bicyclo[3.3.1]nonanes are accessible usin...

Descripción completa

Detalles Bibliográficos
Autores principales: Burns, Alan R., Madec, Amaël G. E., Low, Darryl W., Roy, Iain D., Lam, Hon Wai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659222/
https://www.ncbi.nlm.nih.gov/pubmed/29511516
http://dx.doi.org/10.1039/c5sc00753d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659222/
https://www.ncbi.nlm.nih.gov/pubmed/29511516
http://dx.doi.org/10.1039/c5sc00753d

Ejemplares similares