Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites

OBJECTIVE—: Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-ind...

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Detalles Bibliográficos
Autores principales: Feng, Shuang, Bowden, Neil, Fragiadaki, Maria, Souilhol, Celine, Hsiao, Sarah, Mahmoud, Marwa, Allen, Scott, Pirri, Daniela, Ayllon, Blanca Tardajos, Akhtar, Shamima, Thompson, A.A. Roger, Jo, Hanjoong, Weber, Christian, Ridger, Victoria, Schober, Andreas, Evans, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659306/
https://www.ncbi.nlm.nih.gov/pubmed/28882872
http://dx.doi.org/10.1161/ATVBAHA.117.309249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659306/
https://www.ncbi.nlm.nih.gov/pubmed/28882872
http://dx.doi.org/10.1161/ATVBAHA.117.309249

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