CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry

Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several c...

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Detalles Bibliográficos
Autores principales: Fros, Jelke Jan, Dietrich, Isabelle, Alshaikhahmed, Kinda, Passchier, Tim Casper, Evans, David John, Simmonds, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659819/
https://www.ncbi.nlm.nih.gov/pubmed/28960178
http://dx.doi.org/10.7554/eLife.29112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659819/
https://www.ncbi.nlm.nih.gov/pubmed/28960178
http://dx.doi.org/10.7554/eLife.29112

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