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CpG and UpA dinucleotides in both coding and non-coding regions of echovirus 7 inhibit replication initiation post-entry
Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide frequencies, apparently mimicking host mRNA composition. Artificially increasing CpG/UpA dinucleotides attenuates viruses through an entirely unknown mechanism. Using the echovirus 7 (E7) model in several c...
Autores principales: | Fros, Jelke Jan, Dietrich, Isabelle, Alshaikhahmed, Kinda, Passchier, Tim Casper, Evans, David John, Simmonds, Peter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659819/ https://www.ncbi.nlm.nih.gov/pubmed/28960178 http://dx.doi.org/10.7554/eLife.29112 |
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