Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are oncogenic scaffolds that nucleate the assembly of specific signalling complexes and regulate tyrosine kinase signalling. Both SgK223 and SgK269 form homo- and hetero-oligomers, a mechanism that underpins a diversit...

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Detalles Bibliográficos
Autores principales: Patel, Onisha, Griffin, Michael D. W., Panjikar, Santosh, Dai, Weiwen, Ma, Xiuquan, Chan, Howard, Zheng, Celine, Kropp, Ashleigh, Murphy, James M., Daly, Roger J., Lucet, Isabelle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660093/
https://www.ncbi.nlm.nih.gov/pubmed/29079850
http://dx.doi.org/10.1038/s41467-017-01279-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660093/
https://www.ncbi.nlm.nih.gov/pubmed/29079850
http://dx.doi.org/10.1038/s41467-017-01279-9

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