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Hemodynamic and Pathologic Characterization of the TASK-1(−/−) Mouse Does Not Demonstrate Pulmonary Hypertension

INTRODUCTION: Pulmonary hypertension (PH) carries significant associated morbidity and mortality and the underlying molecular mechanisms of PH are not well understood. Loss-of-function mutations in TASK-1 potassium channels are associated with PH in humans. Although TASK-1 has been considered in the...

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Detalles Bibliográficos
Autores principales: Kitagawa, Melanie G., Reynolds, Julia O., Wehrens, Xander H. T., Bryan, Robert M., Pandit, Lavannya M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660113/
https://www.ncbi.nlm.nih.gov/pubmed/29109948
http://dx.doi.org/10.3389/fmed.2017.00177