In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice. This strategy is often used to reduce undesirable immunogenic responses, accelerating the clinical development of candida...

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Detalles Bibliográficos
Autores principales: Steven, John, Müller, Mischa R., Carvalho, Miguel F., Ubah, Obinna C., Kovaleva, Marina, Donohoe, Gerard, Baddeley, Thomas, Cornock, Dawn, Saunders, Kenneth, Porter, Andrew J., Barelle, Caroline Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660122/
https://www.ncbi.nlm.nih.gov/pubmed/29109729
http://dx.doi.org/10.3389/fimmu.2017.01361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660122/
https://www.ncbi.nlm.nih.gov/pubmed/29109729
http://dx.doi.org/10.3389/fimmu.2017.01361

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