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In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Molecular engineering to increase the percentage identity to common human immunoglobulin sequences of non-human therapeutic antibodies and scaffolds has become standard practice. This strategy is often used to reduce undesirable immunogenic responses, accelerating the clinical development of candida...

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Detalles Bibliográficos
Autores principales:	Steven, John, Müller, Mischa R., Carvalho, Miguel F., Ubah, Obinna C., Kovaleva, Marina, Donohoe, Gerard, Baddeley, Thomas, Cornock, Dawn, Saunders, Kenneth, Porter, Andrew J., Barelle, Caroline Jane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660122/ https://www.ncbi.nlm.nih.gov/pubmed/29109729 http://dx.doi.org/10.3389/fimmu.2017.01361

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