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miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis

Epithelial tumour cells can gain invasive and metastatic capabilities by undergoing an epithelial–mesenchymal transition. Transcriptional regulators and post-transcriptional effectors like microRNAs orchestrate this process of high cellular plasticity and its malignant consequences. Here, using micr...

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Detalles Bibliográficos
Autores principales: Diepenbruck, Maren, Tiede, Stefanie, Saxena, Meera, Ivanek, Robert, Kalathur, Ravi Kiran Reddy, Lüönd, Fabiana, Meyer-Schaller, Nathalie, Christofori, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660124/
https://www.ncbi.nlm.nih.gov/pubmed/29079737
http://dx.doi.org/10.1038/s41467-017-01197-w