Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer’s disease

Cerebral and systemic organ microvascular pathologies coexist with human Alzheimer’s disease (AD) neuropathology. In this study, we hypothesised that both cerebral and systemic microvascular pathologies exist in 4- to 5-month-old male APPswe/PS1dE9 (APP/PS1) transgenic mice prior to the onset of cog...

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Detalles Bibliográficos
Autores principales: Kelly, Patricia, Denver, Paul, Satchell, Simon C., Ackermann, Maximilian, Konerding, Moritz A., Mitchell, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660145/
https://www.ncbi.nlm.nih.gov/pubmed/28741167
http://dx.doi.org/10.1007/s10456-017-9568-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660145/
https://www.ncbi.nlm.nih.gov/pubmed/28741167
http://dx.doi.org/10.1007/s10456-017-9568-3

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