Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice

Huntington’s disease (HD) is an inherited neurodegenerative disorder of which skeletal muscle atrophy is a common feature, and multiple lines of evidence support a muscle-based pathophysiology in HD mouse models. Inhibition of myostatin signaling increases muscle mass, and therapeutic approaches bas...

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Detalles Bibliográficos
Autores principales: Bondulich, Marie K., Jolinon, Nelly, Osborne, Georgina F., Smith, Edward J., Rattray, Ivan, Neueder, Andreas, Sathasivam, Kirupa, Ahmed, Mhoriam, Ali, Nadira, Benjamin, Agnesska C., Chang, Xiaoli, Dick, James R. T., Ellis, Matthew, Franklin, Sophie A., Goodwin, Daniel, Inuabasi, Linda, Lazell, Hayley, Lehar, Adam, Richard-Londt, Angela, Rosinski, Jim, Smith, Donna L., Wood, Tobias, Tabrizi, Sarah J., Brandner, Sebastian, Greensmith, Linda, Howland, David, Munoz-Sanjuan, Ignacio, Lee, Se-Jin, Bates, Gillian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660167/
https://www.ncbi.nlm.nih.gov/pubmed/29079832
http://dx.doi.org/10.1038/s41598-017-14290-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660167/
https://www.ncbi.nlm.nih.gov/pubmed/29079832
http://dx.doi.org/10.1038/s41598-017-14290-3

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