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Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51

FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity. It is known for its role in various regulatory pathways implicated in mood and stress-related disorders, cancer, obesity, Alzheimer’s disease and...

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Detalles Bibliográficos
Autores principales: Kumar, Rajnish, Moche, Martin, Winblad, Bengt, Pavlov, Pavel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660230/
https://www.ncbi.nlm.nih.gov/pubmed/29079741
http://dx.doi.org/10.1038/s41598-017-14731-z