Regulation of HSVtk gene by endogenous microRNA-122a in liver cell lines as suicide gene therapy

AIM: Here, we use miR-122a that exhibits liver-specific expression for developing a post-transcriptional regulative system mediated by microRNAs. BACKGROUND: Gene therapy with adenovirus (Ad) vectors that express herpes simplex virus thymidine kinase (HSVtk) and ganciclovir (GCV) have been suggested...

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Detalles Bibliográficos
Autores principales: Ghanbari, Maryam, Saberfar, Esmaeil, Goodarzi, Zahra, Lashini, Hadi, Ghanbari, Sahar, Karamimanesh, Mojtaba, Baesi, Kazem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660270/
https://www.ncbi.nlm.nih.gov/pubmed/29118936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660270/
https://www.ncbi.nlm.nih.gov/pubmed/29118936

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