Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient mice

BACKGROUND: Chronic increases in the levels of the inflammatory cytokine interleukin-6 (IL-6) in serum and skeletal muscle are thought to contribute to the progression of muscular dystrophy. Dystrophin/utrophin double-knockout (dKO) mice develop a more severe and progressive muscular dystrophy than...

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Detalles Bibliográficos
Autores principales: Wada, Eiji, Tanihata, Jun, Iwamura, Akira, Takeda, Shin’ichi, Hayashi, Yukiko K., Matsuda, Ryoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660454/
https://www.ncbi.nlm.nih.gov/pubmed/29078808
http://dx.doi.org/10.1186/s13395-017-0140-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660454/
https://www.ncbi.nlm.nih.gov/pubmed/29078808
http://dx.doi.org/10.1186/s13395-017-0140-z

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