CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

In this study, we report that the tetraspanin CD81 enhances HIV-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction of CD81 with the deoxynucleoside triphosphate phosphohydrolase SAMHD1. This interaction prevents the endosomal accumulation and favours the prote...

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Detalles Bibliográficos
Autores principales: Rocha-Perugini, Vera, Suárez, Henar, Álvarez, Susana, López-Martín, Soraya, Lenzi, Gina M., Vences-Catalán, Felipe, Levy, Shoshana, Kim, Baek, Muñoz-Fernández, María A., Sánchez-Madrid, Francisco, Yáñez-Mó, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660623/
https://www.ncbi.nlm.nih.gov/pubmed/28871089
http://dx.doi.org/10.1038/s41564-017-0019-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660623/
https://www.ncbi.nlm.nih.gov/pubmed/28871089
http://dx.doi.org/10.1038/s41564-017-0019-0

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