Cargando…

CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels

In this study, we report that the tetraspanin CD81 enhances HIV-1 reverse transcription in HIV-1-infected cells. This is enabled by the direct interaction of CD81 with the deoxynucleoside triphosphate phosphohydrolase SAMHD1. This interaction prevents the endosomal accumulation and favours the prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rocha-Perugini, Vera, Suárez, Henar, Álvarez, Susana, López-Martín, Soraya, Lenzi, Gina M., Vences-Catalán, Felipe, Levy, Shoshana, Kim, Baek, Muñoz-Fernández, María A., Sánchez-Madrid, Francisco, Yáñez-Mó, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660623/ https://www.ncbi.nlm.nih.gov/pubmed/28871089 http://dx.doi.org/10.1038/s41564-017-0019-0

Ejemplares similares

dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages
por: Hollenbaugh, Joseph A, et al.
Publicado: (2014)

A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei
por: Antequera-Parrilla, Pablo, et al.
Publicado: (2023)

Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages
por: Bowen, Nicole E., et al.
Publicado: (2023)

The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592
por: Tramentozzi, Elisa, et al.
Publicado: (2018)

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis
por: Morris, Elizabeth R., et al.
Publicado: (2020)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
por: Schüssler, Moritz, et al.
Publicado: (2023)

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R(p)- and S(p)-dNTPαS Diastereomers
por: Morris, Elizabeth R., et al.
Publicado: (2021)

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4(+) T-lymphocytes cannot be upregulated by interferons
por: St Gelais, Corine, et al.
Publicado: (2012)

Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages
por: Shepard, Caitlin, et al.
Publicado: (2019)

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance
por: Schmidt, Tobias T, et al.
Publicado: (2019)

dNTP Supply Gene Expression Patterns after P53 Loss
por: Radivoyevitch, Tomas, et al.
Publicado: (2012)

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools
por: Kumar, Dinesh, et al.
Publicado: (2011)

Fatty acid carbon is essential for dNTP synthesis in endothelial cells
por: Schoors, Sandra, et al.
Publicado: (2015)

Chl1 helicase controls replication fork progression by regulating dNTP pools
por: Batté, Amandine, et al.
Publicado: (2022)

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools
por: Tsaponina, Olga, et al.
Publicado: (2011)

Reciprocal regulation of autophagy and dNTP pools in human cancer cells
por: Chen, Wei, et al.
Publicado: (2014)

Suppression of the E. coli SOS response by dNTP pool changes
por: Maslowska, Katarzyna H., et al.
Publicado: (2015)

Catalytic properties of RNA polymerases IV and V: accuracy, nucleotide incorporation and rNTP/dNTP discrimination
por: Marasco, Michelle, et al.
Publicado: (2017)

Deep sequencing analysis of mutations resulting from the incorporation of dNTP analogs
por: Petrie, Katherine L., et al.
Publicado: (2010)

Characterization of purple acid phosphatases involved in extracellular dNTP utilization in Stylosanthes
por: Liu, Pan-Dao, et al.
Publicado: (2016)

An essential role for dNTP homeostasis following CDK-induced replication stress
por: Pai, Chen-Chun, et al.
Publicado: (2019)

S phase block following MEC1(ATR) inactivation occurs without severe dNTP depletion
por: Earp, Caroline, et al.
Publicado: (2015)

Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells
por: Qu, Jia, et al.
Publicado: (2017)

S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion
por: Giannattasio, Michele, et al.
Publicado: (2017)

MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
por: Scaletti, Emma Rose, et al.
Publicado: (2020)

Correction: Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells
por: Qu, Jia, et al.
Publicado: (2017)

Tetraspanins, Another Piece in the HIV-1 Replication Puzzle
por: Suárez, Henar, et al.
Publicado: (2018)

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint
por: Kumar, Dinesh, et al.
Publicado: (2010)

Elevated dNTP levels suppress hyper-recombination in Saccharomyces cerevisiae S-phase checkpoint mutants
por: Fasullo, Michael, et al.
Publicado: (2010)

Genome-wide analysis of the specificity and mechanisms of replication infidelity driven by imbalanced dNTP pools
por: Watt, Danielle L., et al.
Publicado: (2016)

Differential control of dNTP biosynthesis and genome integrity maintenance by the dUTPase superfamily enzymes
por: Hirmondo, Rita, et al.
Publicado: (2017)

Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells
por: Harada, Yoichiro, et al.
Publicado: (2023)

CD81 is a novel immunotherapeutic target for B cell lymphoma
por: Vences-Catalán, Felipe, et al.
Publicado: (2019)

Mismatched and Matched dNTP Incorporation by DNA Polymerase β Proceed via Analogous Kinetic Pathways
por: Roettger, Michelle P., et al.
Publicado: (2008)

Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity
por: Buckland, Robert J., et al.
Publicado: (2014)

ERK Inhibitor Enhances Everolimus Efficacy through the Attenuation of dNTP Pools in Renal Cell Carcinoma
por: Zou, Yun, et al.
Publicado: (2019)

Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools
por: Kychygina, Anna, et al.
Publicado: (2021)

RNase H activities counteract a toxic effect of Polymerase η in cells replicating with depleted dNTP pools
por: Meroni, Alice, et al.
Publicado: (2019)

Leishmania Induces Survival, Proliferation and Elevated Cellular dNTP Levels in Human Monocytes Promoting Acceleration of HIV Co-Infection
por: Mock, David J., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cjnafmvfpqha1493l4511f1e0o