Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

Here we report on the crystal structure and cleavage assays of a four-way junctional twister-sister self-cleaving ribozyme. Notably, 11 conserved spatially separated loop nucleotides are brought into close proximity at the ribozyme core through long-range interactions mediated by hydrated Mg(2+) cat...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Luqian, Mairhofer, Elisabeth, Teplova, Marianna, Zhang, Ye, Ma, Jinbiao, Patel, Dinshaw J., Micura, Ronald, Ren, Aiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660989/
https://www.ncbi.nlm.nih.gov/pubmed/29081514
http://dx.doi.org/10.1038/s41467-017-01276-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660989/
https://www.ncbi.nlm.nih.gov/pubmed/29081514
http://dx.doi.org/10.1038/s41467-017-01276-y

Ejemplares similares