Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains

The overexpression of RND-type exporters is one of the main causes of multidrug resistance (MDR) in Gram-negative pathogens. In RND transporters, such as Escherichia coli's main efflux pump AcrB, drug efflux occurs in the porter domain, while protons flow through the transmembrane domain: remot...

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Detalles Bibliográficos
Autores principales: Zwama, Martijn, Hayashi, Katsuhiko, Sakurai, Keisuke, Nakashima, Ryosuke, Kitagawa, Kimie, Nishino, Kunihiko, Yamaguchi, Akihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661021/
https://www.ncbi.nlm.nih.gov/pubmed/29118749
http://dx.doi.org/10.3389/fmicb.2017.02095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661021/
https://www.ncbi.nlm.nih.gov/pubmed/29118749
http://dx.doi.org/10.3389/fmicb.2017.02095

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