Cardiac and renal upregulation of Nox2 and NF‐κB and repression of Nox4 and Nrf2 in season‐ and diabetes‐mediated models of vascular oxidative stress in guinea‐pig and rat

The superoxide‐forming NADPH oxidase homologues, Nox1, Nox2, and Nox5, seem to mediate the pro‐atherosclerotic vascular phenotype. The hydrogen peroxide‐forming Nox4 afforded vascular protection, likely via NF‐E2‐related factor‐2 (Nrf2) activation and/or Nox2 downregulation in transgenic mice. We hy...

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Detalles Bibliográficos
Autores principales: Gajos‐Draus, Anna, Duda, Monika, Beręsewicz, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661235/
https://www.ncbi.nlm.nih.gov/pubmed/29084841
http://dx.doi.org/10.14814/phy2.13474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661235/
https://www.ncbi.nlm.nih.gov/pubmed/29084841
http://dx.doi.org/10.14814/phy2.13474

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