Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation

The underlying anticancer effects of butyrate, an end-product of the intestinal microbial fermentation of dietary fiber, remain elusive. Here, we report that butyrate promotes cancer cell apoptosis by acting as a SIRT3 inhibitor. Butyrate inhibits SIRT3 both in cultured cells and in vitro. Butyrate-...

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Detalles Bibliográficos
Autores principales: Xu, Sha, Liu, Cai-Xia, Xu, Wei, Huang, Lei, Zhao, Jian-Yuan, Zhao, Shi-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661613/
https://www.ncbi.nlm.nih.gov/pubmed/29263907
http://dx.doi.org/10.1038/sigtrans.2016.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661613/
https://www.ncbi.nlm.nih.gov/pubmed/29263907
http://dx.doi.org/10.1038/sigtrans.2016.35

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