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Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression
Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated the significant inhibitory effects of a novel chemically synthetic peptide (E5) on the CXCR4/...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661635/ https://www.ncbi.nlm.nih.gov/pubmed/29263923 http://dx.doi.org/10.1038/sigtrans.2017.33 |