Targeting the CXCR4/CXCL12 axis with the peptide antagonist E5 to inhibit breast tumor progression

Emerging evidence has demonstrated that stromal cell-derived factor 1 (SDF-1) and its cognate receptor CXCR4 have critical roles in tumorigenesis, angiogenesis and metastasis. In this study, we demonstrated the significant inhibitory effects of a novel chemically synthetic peptide (E5) on the CXCR4/...

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Detalles Bibliográficos
Autores principales: Guo, Hua, Ge, Yangyang, Li, Xiaojin, Yang, Yanlian, Meng, Jie, Liu, Jian, Wang, Chen, Xu, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661635/
https://www.ncbi.nlm.nih.gov/pubmed/29263923
http://dx.doi.org/10.1038/sigtrans.2017.33

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