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Targeting cellular pathways in glioblastoma multiforme
Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor prognosis, short median patient survival and a very limited response to therapies. GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in ce...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661637/ https://www.ncbi.nlm.nih.gov/pubmed/29263927 http://dx.doi.org/10.1038/sigtrans.2017.40 |
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author | Pearson, Joshua R D Regad, Tarik |
author_facet | Pearson, Joshua R D Regad, Tarik |
author_sort | Pearson, Joshua R D |
collection | PubMed |
description | Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor prognosis, short median patient survival and a very limited response to therapies. GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in cell proliferation, survival, migration and angiogenesis. Therefore, efforts that are directed toward better understanding of GBM pathogenesis are essential to the development of efficient therapies that provide hope and extent patient survival. In this review, we outline the alterations commonly associated with GBM pathogenesis and summarize therapeutic strategies that are aimed at targeting aberrant cellular pathways in GBM. |
format | Online Article Text |
id | pubmed-5661637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-56616372017-12-20 Targeting cellular pathways in glioblastoma multiforme Pearson, Joshua R D Regad, Tarik Signal Transduct Target Ther Review Article Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor prognosis, short median patient survival and a very limited response to therapies. GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in cell proliferation, survival, migration and angiogenesis. Therefore, efforts that are directed toward better understanding of GBM pathogenesis are essential to the development of efficient therapies that provide hope and extent patient survival. In this review, we outline the alterations commonly associated with GBM pathogenesis and summarize therapeutic strategies that are aimed at targeting aberrant cellular pathways in GBM. Nature Publishing Group 2017-09-29 /pmc/articles/PMC5661637/ /pubmed/29263927 http://dx.doi.org/10.1038/sigtrans.2017.40 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Review Article Pearson, Joshua R D Regad, Tarik Targeting cellular pathways in glioblastoma multiforme |
title | Targeting cellular pathways in glioblastoma multiforme |
title_full | Targeting cellular pathways in glioblastoma multiforme |
title_fullStr | Targeting cellular pathways in glioblastoma multiforme |
title_full_unstemmed | Targeting cellular pathways in glioblastoma multiforme |
title_short | Targeting cellular pathways in glioblastoma multiforme |
title_sort | targeting cellular pathways in glioblastoma multiforme |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661637/ https://www.ncbi.nlm.nih.gov/pubmed/29263927 http://dx.doi.org/10.1038/sigtrans.2017.40 |
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