Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

BACKGROUND: DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildly elevated homocysteine: MTHFR 677C>T independ...

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Detalhes bibliográficos
Principais autores: Mandaviya, Pooja R., Joehanes, Roby, Aïssi, Dylan, Kühnel, Brigitte, Marioni, Riccardo E., Truong, Vinh, Stolk, Lisette, Beekman, Marian, Bonder, Marc Jan, Franke, Lude, Gieger, Christian, Huan, Tianxiao, Ikram, M. Arfan, Kunze, Sonja, Liang, Liming, Lindemans, Jan, Liu, Chunyu, McRae, Allan F., Mendelson, Michael M., Müller-Nurasyid, Martina, Peters, Annette, Slagboom, P. Eline, Starr, John M., Trégouët, David-Alexandre, Uitterlinden, André G., van Greevenbroek, Marleen M. J., van Heemst, Diana, van Iterson, Maarten, Wells, Philip S., Yao, Chen, Deary, Ian J., Gagnon, France, Heijmans, Bastiaan T., Levy, Daniel, Morange, Pierre-Emmanuel, Waldenberger, Melanie, Heil, Sandra G., van Meurs, Joyce B. J.
Formato: Online Atigo Texto
Idioma:English
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662081/
https://www.ncbi.nlm.nih.gov/pubmed/29084233
http://dx.doi.org/10.1371/journal.pone.0182472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662081/
https://www.ncbi.nlm.nih.gov/pubmed/29084233
http://dx.doi.org/10.1371/journal.pone.0182472

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