Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

BACKGROUND: DNA methylation is affected by the activities of the key enzymes and intermediate metabolites of the one-carbon pathway, one of which involves homocysteine. We investigated the effect of the well-known genetic variant associated with mildly elevated homocysteine: MTHFR 677C>T independ...

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Detalles Bibliográficos
Autores principales: Mandaviya, Pooja R., Joehanes, Roby, Aïssi, Dylan, Kühnel, Brigitte, Marioni, Riccardo E., Truong, Vinh, Stolk, Lisette, Beekman, Marian, Bonder, Marc Jan, Franke, Lude, Gieger, Christian, Huan, Tianxiao, Ikram, M. Arfan, Kunze, Sonja, Liang, Liming, Lindemans, Jan, Liu, Chunyu, McRae, Allan F., Mendelson, Michael M., Müller-Nurasyid, Martina, Peters, Annette, Slagboom, P. Eline, Starr, John M., Trégouët, David-Alexandre, Uitterlinden, André G., van Greevenbroek, Marleen M. J., van Heemst, Diana, van Iterson, Maarten, Wells, Philip S., Yao, Chen, Deary, Ian J., Gagnon, France, Heijmans, Bastiaan T., Levy, Daniel, Morange, Pierre-Emmanuel, Waldenberger, Melanie, Heil, Sandra G., van Meurs, Joyce B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662081/
https://www.ncbi.nlm.nih.gov/pubmed/29084233
http://dx.doi.org/10.1371/journal.pone.0182472

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