Cargando…

Lgr6 is a stem cell marker in mouse skin squamous carcinomas

The G-protein-coupled receptors Lgr4/5/6 are Wnt signalling mediators, but their functions in squamous carcinomas (SCCs) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2- and Lgr6-EGFP-CreERT2- Rosa26/Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Phillips Y., Kandyba, Eve, Jabouille, Arnaud, Sjolund, Jonas, Kumar, Atul, Halliwill, Kyle, McCreery, Melissa, DelRosario, Reyno, Kang, Hio Chung, Wong, Christine E., Seibler, Jost, Beuger, Vincent, Pellegrino, Maurizio, Sciambi, Adam, Eastburn, Dennis J., Balmain, Allan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662105/ https://www.ncbi.nlm.nih.gov/pubmed/28945253 http://dx.doi.org/10.1038/ng.3957

Ejemplares similares

Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer
por: Halliwill, Kyle D., et al.
Publicado: (2016)

Gene networks reveal stem-cell state convergence during preneoplasia and progression to malignancy in multistage skin carcinogenesis
por: Taylor, Mark A., et al.
Publicado: (2023)

Multi-color lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis
por: Reeves, Melissa Q., et al.
Publicado: (2018)

Allele-Specific Deletions in Mouse Tumors Identify Fbxw7 as Germline Modifier of Tumor Susceptibility
por: Perez-Losada, Jesus, et al.
Publicado: (2012)

Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice
por: Kang, Hio Chung, et al.
Publicado: (2012)

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer
por: Westcott, Peter M. K., et al.
Publicado: (2014)

Picoinjection Enables Digital Detection of RNA with Droplet RT-PCR
por: Eastburn, Dennis J., et al.
Publicado: (2013)

Identification and genetic analysis of cancer cells with PCR-activated cell sorting
por: Eastburn, Dennis J., et al.
Publicado: (2014)

Desarrollo económico y política nacional : el Ministerio de Fomento de Guatemala, 1871-1885 /
por: McCreery, David
Publicado: (1981)

Rural Guatemala, 1760-1940 /
por: McCreery, David
Publicado: (1994)

RNA-Seq following PCR-based sorting reveals rare cell transcriptional signatures
por: Pellegrino, Maurizio, et al.
Publicado: (2016)

Microfluidic droplet enrichment for targeted sequencing
por: Eastburn, Dennis J., et al.
Publicado: (2015)

Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice
por: Rose Li, Yun, et al.
Publicado: (2020)

Raman Spectroscopy for Chemical Analysis
por: McCreery, Richard L
Publicado: (2000)

Effects of electronic coupling and electrostatic potential on charge transport in carbon-based molecular electronic junctions
por: McCreery, Richard L
Publicado: (2016)

Interactions Between Wildtype and Mutant Ras Genes in Lung and Skin Carcinogenesis
por: To, Minh D., et al.
Publicado: (2012)

Pure sensory stroke due to brainstem lesion
por: McCreery, Ryan, et al.
Publicado: (2019)

An Unusual Case of Stridor: Severe Tracheal Narrowing Secondary to Esophageal Food Impaction
por: McCreery, Ryan, et al.
Publicado: (2019)

An Unusual Presentation of Cholecystoduodenal Fistula: Abdominal Pain out of Proportion to Exam
por: McCreery, Ryan, et al.
Publicado: (2019)

Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells
por: Chen, Wei-Ching, et al.
Publicado: (2021)

1874. Adherence to Practice Guidelines for Treating Diabetic Foot Infections: An Opportunity for Syndromic Stewardship
por: McCreery, Randy, et al.
Publicado: (2018)

Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats
por: Pikov, Victor, et al.
Publicado: (2020)

Configuring intracortical microelectrode arrays and stimulus parameters to minimize neuron loss during prolonged intracortical electrical stimulation
por: McCreery, Douglas, et al.
Publicado: (2021)

LGR5 and LGR6 in stem cell biology and ovarian cancer
por: Schindler, Adam J., et al.
Publicado: (2017)

Emerging role for leucine-rich repeat-containing G-protein-coupled receptors LGR5 and LGR4 in cancer stem cells
por: Nakata, Susumu, et al.
Publicado: (2014)

LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation
por: Tsai, Yu-Hwai, et al.
Publicado: (2016)

Prediction of calculated future cardiovascular disease by monocyte count in an asymptomatic population
por: Waterhouse, Deirdre F, et al.
Publicado: (2008)

Consensus or Deadlock? Consequences of Simple Behavioral Rules for Coordination in Group Decisions
por: McCreery, Helen F., et al.
Publicado: (2016)

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
por: Lee, Joo-Hyeon, et al.
Publicado: (2017)

High chemoselectivity in the phenol synthesis
por: Rudolph, Matthias, et al.
Publicado: (2011)

Longitudinal Speech Recognition in Noise in Children: Effects of Hearing Status and Vocabulary
por: Walker, Elizabeth A., et al.
Publicado: (2019)

336: Compass trends and the potential impact of coronavirus
por: Scott, R., et al.
Publicado: (2021)

Impact of a syndrome-specific antibiotic stewardship intervention on antipseudomonal antibiotic use in inpatient diabetic foot infection management
por: McCreery, Randy J., et al.
Publicado: (2023)

Polyethylene glycol intestinal lavage in addition to usual antibiotic treatment for severe Clostridium difficile colitis: a randomised controlled pilot study
por: McCreery, Greig, et al.
Publicado: (2017)

Assessing the Perceptions of Inspiratory Muscle Training in Children With Cystic Fibrosis and Their Multidisciplinary Team: Mixed-Methods Study
por: McCreery, Jessica L, et al.
Publicado: (2018)

Auditory, Cognitive, and Linguistic Factors Predict Speech Recognition in Adverse Listening Conditions for Children With Hearing Loss
por: McCreery, Ryan W., et al.
Publicado: (2019)

Hysteresis stabilizes dynamic control of self-assembled army ant constructions
por: McCreery, Helen F., et al.
Publicado: (2022)

The efficacy and complications of retropubic tension‐free vaginal tapes after 20 years: A prospective observational study
por: O'Leary, Bobby D., et al.
Publicado: (2022)

LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea
por: Żak, Magdalena, et al.
Publicado: (2016)

Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea
por: Cheng, Cheng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eufoo19cgs2tpqe7743c3l9fan