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Genome-wide screen of gamma-secretase–mediated intramembrane cleavage of receptor tyrosine kinases
Receptor tyrosine kinases (RTKs) have been demonstrated to signal via regulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavage by gamma-secretase leads to release of a soluble intracellular receptor fragment with functional activity. For most RTKs, howe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662267/ https://www.ncbi.nlm.nih.gov/pubmed/28904208 http://dx.doi.org/10.1091/mbc.E17-04-0261 |