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Genome-wide screen of gamma-secretase–mediated intramembrane cleavage of receptor tyrosine kinases

Receptor tyrosine kinases (RTKs) have been demonstrated to signal via regulated intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane cleavage by gamma-secretase leads to release of a soluble intracellular receptor fragment with functional activity. For most RTKs, howe...

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Detalles Bibliográficos
Autores principales:	Merilahti, Johannes A. M., Ojala, Veera K., Knittle, Anna M., Pulliainen, Arto T., Elenius, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662267/ https://www.ncbi.nlm.nih.gov/pubmed/28904208 http://dx.doi.org/10.1091/mbc.E17-04-0261

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