Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity

Adoptive transfer of high-affinity chimeric antigen receptor (CAR) T cells targeting hematological cancers has yielded impressive clinical results. However, safety concerns regarding target expression on healthy tissue and poor efficacy have hampered application to solid tumors. Here, a panel of aff...

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Detalles Bibliográficos
Autores principales: Park, Spencer, Shevlin, Enda, Vedvyas, Yogindra, Zaman, Marjan, Park, Susan, Hsu, Yen-Michael S., Min, Irene M., Jin, Moonsoo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662687/
https://www.ncbi.nlm.nih.gov/pubmed/29085043
http://dx.doi.org/10.1038/s41598-017-14749-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662687/
https://www.ncbi.nlm.nih.gov/pubmed/29085043
http://dx.doi.org/10.1038/s41598-017-14749-3

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