Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s

Cellular protein homeostasis depends on heat shock proteins 70 kDa (Hsp70s), a class of ubiquitous and highly conserved molecular chaperone. Key to the chaperone activity is an ATP-induced allosteric regulation of polypeptide substrate binding and release. To illuminate the molecular mechanism of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jiao, Zong, Yinong, Su, Jiayue, Li, Hongtao, Zhu, Huanyu, Columbus, Linda, Zhou, Lei, Liu, Qinglian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662698/
https://www.ncbi.nlm.nih.gov/pubmed/29084938
http://dx.doi.org/10.1038/s41467-017-01310-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662698/
https://www.ncbi.nlm.nih.gov/pubmed/29084938
http://dx.doi.org/10.1038/s41467-017-01310-z

Ejemplares similares