Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

The ATRX–DAXX histone chaperone complex incorporates the histone variant H3.3 at heterochromatic regions in a replication-independent manner. Here, we present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX. We use single amino acid substitutions in DAXX tha...

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Detalles Bibliográficos
Autores principales: Hoelper, Dominik, Huang, Hongda, Jain, Aayushi Y., Patel, Dinshaw J., Lewis, Peter W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662737/
https://www.ncbi.nlm.nih.gov/pubmed/29084956
http://dx.doi.org/10.1038/s41467-017-01206-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662737/
https://www.ncbi.nlm.nih.gov/pubmed/29084956
http://dx.doi.org/10.1038/s41467-017-01206-y

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