Cargando…

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

The ATRX–DAXX histone chaperone complex incorporates the histone variant H3.3 at heterochromatic regions in a replication-independent manner. Here, we present a high-resolution x-ray crystal structure of an interaction surface between ATRX and DAXX. We use single amino acid substitutions in DAXX tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoelper, Dominik, Huang, Hongda, Jain, Aayushi Y., Patel, Dinshaw J., Lewis, Peter W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662737/ https://www.ncbi.nlm.nih.gov/pubmed/29084956 http://dx.doi.org/10.1038/s41467-017-01206-y

Ejemplares similares

New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
por: Voon, Hsiao P.J., et al.
Publicado: (2016)

Structural basis for DAXX interaction with ATRX
por: Wang, Xiaoman, et al.
Publicado: (2017)

Structural and biochemical characterization of DAXX-ATRX interaction
por: Li, Zhuang, et al.
Publicado: (2017)

The histone chaperone function of Daxx is dispensable for embryonic development
por: Sun, Chang, et al.
Publicado: (2023)

Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX
por: de Nonneville, Alexandre, et al.
Publicado: (2021)

ATRX/DAXX: Guarding the Genome against the Hazards of ALT
por: Clatterbuck Soper, Sarah F., et al.
Publicado: (2023)

A role for the histone chaperone DAXX in the structural organization of heterochromatin
por: Rapkin, Lindsy M, et al.
Publicado: (2013)

The histone chaperone DAXX maintains the structural organization of heterochromatin domains
por: Rapkin, Lindsy M., et al.
Publicado: (2015)

ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity
por: Lovejoy, Courtney A., et al.
Publicado: (2020)

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX
por: Delbarre, Erwan, et al.
Publicado: (2017)

Formal reply to “Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX”
por: Feuerbach, Lars
Publicado: (2021)

Targeting Telomerase and ATRX/DAXX Inducing Tumor Senescence and Apoptosis in the Malignant Glioma
por: Fan, Hueng-Chuen, et al.
Publicado: (2019)

DAXX-ATRX regulation of p53 chromatin binding and DNA damage response
por: Gulve, Nitish, et al.
Publicado: (2022)

Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas
por: Sun, Chang, et al.
Publicado: (2022)

Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX
por: Hu, Yang, et al.
Publicado: (2016)

DAXX/ATRX and MEN1 genes are strong prognostic markers in pancreatic neuroendocrine tumors
por: Park, Joo Kyung, et al.
Publicado: (2017)

ATRX links atypical histone methylation recognition mechanisms to human brain function
por: Iwase, Shigeki, et al.
Publicado: (2011)

Structural basis underlying viral hijacking of a histone chaperone complex
por: Huang, Hongda, et al.
Publicado: (2016)

Calcium-Dependent Dephosphorylation of the Histone Chaperone DAXX Regulates H3.3 Loading and Transcription upon Neuronal Activation
por: Michod, David, et al.
Publicado: (2012)

Prognostic Significance of Altered ATRX/DAXX Gene in Pancreatic Neuroendocrine Tumors: A Meta-Analysis
por: Wang, Fei, et al.
Publicado: (2021)

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
por: Chan, Chang S., et al.
Publicado: (2018)

EBV Tegument Protein BNRF1 Disrupts DAXX-ATRX to Activate Viral Early Gene Transcription
por: Tsai, Kevin, et al.
Publicado: (2011)

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes
por: Schreiner, Sabrina, et al.
Publicado: (2013)

Prognostic value of DAXX/ATRX loss of expression and ALT activation in PanNETs: is it time for clinical implementation?
por: Marinoni, Ilaria
Publicado: (2022)

DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network
por: Hammond, Colin M., et al.
Publicado: (2021)

The CENP-T/-W complex is a binding partner of the histone chaperone FACT
por: Prendergast, Lisa, et al.
Publicado: (2016)

Structure–function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2
por: Chen, Shoudeng, et al.
Publicado: (2015)

Immunohistochemical analyses of the expression profiles of INSM1, ATRX, DAXX and DLL3 in solid papillary carcinomas of the breast
por: Yanai, Hirotsugu, et al.
Publicado: (2022)

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size
por: Hackeng, Wenzel M, et al.
Publicado: (2022)

Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization
por: Park, Jinyoung, et al.
Publicado: (2018)

H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements
por: Zink, Lisa-Maria, et al.
Publicado: (2017)

CENP-B protects centromere chromatin integrity by facilitating histone deposition via the H3.3-specific chaperone Daxx
por: Morozov, Viacheslav M., et al.
Publicado: (2017)

Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
por: Falcinelli, Marta, et al.
Publicado: (2023)

DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network
por: Carraro, Massimo, et al.
Publicado: (2023)

The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture
por: Salomoni, Paolo
Publicado: (2013)

KRAS and DAXX/ATRX Gene Mutations Are Correlated with the Clinicopathological Features, Advanced Diseases, and Poor Prognosis in Chinese Patients with Pancreatic Neuroendocrine Tumors
por: Yuan, Fei, et al.
Publicado: (2014)

Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma
por: Slatter, Tania L., et al.
Publicado: (2015)

Histone acetylation-independent transcription stimulation by a histone chaperone
por: Kato, Kohsuke, et al.
Publicado: (2007)

Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.
por: Kovatcheva, Marta, et al.
Publicado: (2017)

HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX
por: Nye, Jonathan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0rfhspm3ei1braqgoitj41uh05