Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway

Isoniazid (INH), a widely used first-line antitubercular drug, has been noted to be associated with hepatotoxicity. In spite of extensive researches over many decades, the mechanism of INH-induced hepatotoxicity still remains poorly understood. Recently, mitochondrial toxicity has been emerging as a...

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Detalles Bibliográficos
Autores principales: Zhang, Tianguang, Ikejima, Takashi, Li, Lizhong, Wu, Ruiqin, Yuan, Xiaoyan, Zhao, Jun, Wang, Yimei, Peng, Shuangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662931/
https://www.ncbi.nlm.nih.gov/pubmed/29123480
http://dx.doi.org/10.3389/fphar.2017.00753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662931/
https://www.ncbi.nlm.nih.gov/pubmed/29123480
http://dx.doi.org/10.3389/fphar.2017.00753

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