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Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. R...

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Detalles Bibliográficos
Autores principales: Walkley, Carl R., Li, Jin Billy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663115/
https://www.ncbi.nlm.nih.gov/pubmed/29084589
http://dx.doi.org/10.1186/s13059-017-1347-3
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author Walkley, Carl R.
Li, Jin Billy
author_facet Walkley, Carl R.
Li, Jin Billy
author_sort Walkley, Carl R.
collection PubMed
description One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing.
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spelling pubmed-56631152017-11-01 Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs Walkley, Carl R. Li, Jin Billy Genome Biol Review One of the most prevalent forms of post-transcritpional RNA modification is the conversion of adenosine nucleosides to inosine (A-to-I), mediated by the ADAR family of enzymes. The functional requirement and regulatory landscape for the majority of A-to-I editing events are, at present, uncertain. Recent studies have identified key in vivo functions of ADAR enzymes, informing our understanding of the biological importance of A-to-I editing. Large-scale studies have revealed how editing is regulated both in cis and in trans. This review will explore these recent studies and how they broaden our understanding of the functions and regulation of ADAR-mediated RNA editing. BioMed Central 2017-10-30 /pmc/articles/PMC5663115/ /pubmed/29084589 http://dx.doi.org/10.1186/s13059-017-1347-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Walkley, Carl R.
Li, Jin Billy
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
title Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
title_full Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
title_fullStr Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
title_full_unstemmed Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
title_short Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
title_sort rewriting the transcriptome: adenosine-to-inosine rna editing by adars
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663115/
https://www.ncbi.nlm.nih.gov/pubmed/29084589
http://dx.doi.org/10.1186/s13059-017-1347-3
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