Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story

Plants are a promising alternative for the production of biotherapeutics. Manufacturing in-planta adds plant specific glycans. To understand immunogenic potential of these glycans, we developed a validated method to detect plant specific glycan antibodies in human serum. Using this assay, low preval...

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Detalles Bibliográficos
Autores principales: Rup, Bonita, Alon, Sari, Amit-Cohen, Bat-Chen, Brill Almon, Einat, Chertkoff, Raul, Tekoah, Yoram, Rudd, Pauline M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663370/
https://www.ncbi.nlm.nih.gov/pubmed/29088235
http://dx.doi.org/10.1371/journal.pone.0186211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663370/
https://www.ncbi.nlm.nih.gov/pubmed/29088235
http://dx.doi.org/10.1371/journal.pone.0186211

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