Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

[Image: see text] Methionyl-tRNA synthetase (MetRS) has been chemically validated as a drug target in the kinetoplastid parasite Trypanosoma brucei. In the present study, we investigate the validity of this target in the related trypanosomatid Leishmania donovani. Following development of a robust h...

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Detalles Bibliográficos
Autores principales: Torrie, Leah S., Brand, Stephen, Robinson, David A., Ko, Eun Jung, Stojanovski, Laste, Simeons, Frederick R. C., Wyllie, Susan, Thomas, John, Ellis, Lucy, Osuna-Cabello, Maria, Epemolu, Ola, Nühs, Andrea, Riley, Jennifer, MacLean, Lorna, Manthri, Sujatha, Read, Kevin D., Gilbert, Ian H., Fairlamb, Alan H., De Rycker, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395/
https://www.ncbi.nlm.nih.gov/pubmed/28967262
http://dx.doi.org/10.1021/acsinfecdis.7b00047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395/
https://www.ncbi.nlm.nih.gov/pubmed/28967262
http://dx.doi.org/10.1021/acsinfecdis.7b00047

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