HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide

Human immunodeficiency virus (HIV) infection is an independent risk factor for cardiovascular disease. This risk is magnified by certain antiretrovirals, particularly the protease inhibitor ritonavir, but the pathophysiology of this connection is unknown. We postulated that a major mechanism for ant...

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Detalles Bibliográficos
Autores principales: Laurence, Jeffrey, Elhadad, Sonia, Robison, Tyler, Terry, Hunter, Varshney, Rohan, Woolington, Sean, Ghafoory, Shahrouz, Choi, Mary E., Ahamed, Jasimuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663426/
https://www.ncbi.nlm.nih.gov/pubmed/29088262
http://dx.doi.org/10.1371/journal.pone.0187185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663426/
https://www.ncbi.nlm.nih.gov/pubmed/29088262
http://dx.doi.org/10.1371/journal.pone.0187185

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