Cargando…

HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide

Human immunodeficiency virus (HIV) infection is an independent risk factor for cardiovascular disease. This risk is magnified by certain antiretrovirals, particularly the protease inhibitor ritonavir, but the pathophysiology of this connection is unknown. We postulated that a major mechanism for ant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Laurence, Jeffrey, Elhadad, Sonia, Robison, Tyler, Terry, Hunter, Varshney, Rohan, Woolington, Sean, Ghafoory, Shahrouz, Choi, Mary E., Ahamed, Jasimuddin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663426/ https://www.ncbi.nlm.nih.gov/pubmed/29088262 http://dx.doi.org/10.1371/journal.pone.0187185

Ejemplares similares

HIV-associated cardiovascular disease: importance of platelet activation and cardiac fibrosis in the setting of specific antiretroviral therapies
por: Laurence, Jeffrey, et al.
Publicado: (2018)

In Vitro and In Vivo Evidence that Thrombospondin-1 (TSP-1) Contributes to Stirring- and Shear-Dependent Activation of Platelet-Derived TGF-β1
por: Ahamed, Jasimuddin, et al.
Publicado: (2009)

Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator
por: Kouzbari, Karim, et al.
Publicado: (2019)

Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver
por: Gostynska, Sandra, et al.
Publicado: (2022)

Characteristics of exogenous carbon monoxide deliveries
por: Hu, Hui-jun, et al.
Publicado: (2016)

Defibrotide mitigates endothelial cell injury induced by plasmas from patients with COVID-19 and related vasculopathies
por: Elhadad, Sonia, et al.
Publicado: (2023)

Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches
por: Ahamed, Jasimuddin, et al.
Publicado: (2022)

Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage
por: Laurence, Jeffrey, et al.
Publicado: (2022)

pVHL-mediated SMAD3 degradation suppresses TGF-β signaling
por: Zhou, Jun, et al.
Publicado: (2021)

Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
por: Seshadri, Madhav, et al.
Publicado: (2020)

Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse
por: Ghafoory, Shahrouz, et al.
Publicado: (2013)

Severe aortic stenosis patient risk during the COVID-19 pandemic
por: Ahamed, Jasimuddin
Publicado: (2020)

Exogenous Carbon Monoxide Produces Rapid Antidepressant- and Anxiolytic-Like Effects
por: Luo, Yixiao, et al.
Publicado: (2021)

Exogenous carbon monoxide improves neuronal differentiation: a near-death experience
por: Almeida, Ana S, et al.
Publicado: (2015)

Oxygen Gradient Induced in Microfluidic Chips Can Be Used as a Model for Liver Zonation
por: Ghafoory, Shahrouz, et al.
Publicado: (2022)

Higher Tissue Factor (TF) Expression in the Lungs of COVID-19 Pneumonia Patients Than Patients with Acute Respiratory Distress Syndrome: Association with Thrombi Formation
por: Subrahmanian, Sandeep, et al.
Publicado: (2020)

Exogenous carbon monoxide suppresses adaptive response induced in zebrafish embryos in vivo by microbeam protons
por: Choi, Viann Wing Yan, et al.
Publicado: (2014)

Suppressive effect of exogenous carbon monoxide on endotoxin-stimulated platelet over-activation via the glycoprotein-mediated PI3K-Akt-GSK3β pathway
por: Liu, Dadong, et al.
Publicado: (2016)

Low Concentration of Exogenous Carbon Monoxide Modulates Radiation-Induced Bystander Effect in Mammalian Cell Cluster Model
por: Wu, Wenqing, et al.
Publicado: (2016)

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice
por: Cheng, Xinlai, et al.
Publicado: (2020)

Tissue factor upregulation is associated with SARS‐CoV‐2 in the lungs of COVID‐19 patients
por: Subrahmanian, Sandeep, et al.
Publicado: (2021)

MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti‐MASP2 antibody narsoplimab
por: Elhadad, S., et al.
Publicado: (2020)

Exogenous Carbon Monoxide Decreases Sepsis-Induced Acute Kidney Injury and Inhibits NLRP3 Inflammasome Activation in Rats
por: Wang, Peng, et al.
Publicado: (2015)

Exogenous carbon monoxide protects against mitochondrial DNA-induced hippocampal pyroptosis in a model of hemorrhagic shock and resuscitation
por: Fu, Lan, et al.
Publicado: (2020)

TGF-β2 silencing to target biliary-derived liver diseases
por: Dropmann, Anne, et al.
Publicado: (2020)

Inhibition of platelet aggregation by carbon monoxide-releasing molecules (CO-RMs): comparison with NO donors
por: Chlopicki, Stefan, et al.
Publicado: (2012)

Species Differences in Platelet Protease-Activated Receptors
por: Renna, Stephanie A., et al.
Publicado: (2023)

Effect of Exogenous Fetuin-A on TGF-β/Smad Signaling in Hepatic Stellate Cells
por: Zhou, Yulai, et al.
Publicado: (2016)

A Novel Role of Exogenous Carbon Monoxide on Protecting Cardiac Function and Improving Survival against Sepsis via Mitochondrial Energetic Metabolism Pathway
por: Wang, Xu, et al.
Publicado: (2014)

Exogenous carbon monoxide inhibits neutrophil infiltration in LPS-induced sepsis by interfering with FPR1 via p38 MAPK but not GRK2
por: Wang, Xu, et al.
Publicado: (2016)

Carbon Monoxide Being Hydrogen Sulfide and Nitric Oxide Molecular Sibling, as Endogenous and Exogenous Modulator of Oxidative Stress and Antioxidative Mechanisms in the Digestive System
por: Korbut, Edyta, et al.
Publicado: (2020)

Carbon monoxide toxicity /
Publicado: (2000)

Carbon monoxide poisoning
por: Singh, H., et al.
Publicado: (2010)

Carbon Monoxide Asphyxia
Publicado: (1939)

Carbon monoxide poisoning
por: Kinoshita, Hiroshi, et al.
Publicado: (2020)

Mathematical models of the uptake of carbon monoxide on hemoglobin at low carbon monoxide levels.
por: Joumard, R, et al.
Publicado: (1981)

Cross talks between the immune and lymphatic endothelial cells regulate inflammatory lymph node lymphangiogenesis: defining a new therapeutic approach
por: Elhadad, Sonia
Publicado: (2013)

Effects of exogenous protease addition on fermentation and nutritive value of rehydrated corn and sorghum grains silages
por: Roseira, João Paulo Santos, et al.
Publicado: (2023)

Exogenous Heparan Sulfate Enhances the TGF-β3-Induced Chondrogenesis in Human Mesenchymal Stem Cells by Activating TGF-β/Smad Signaling
por: Chen, Juan, et al.
Publicado: (2016)

High Performance of Carbon Monoxide Gas Sensor Based on a Novel PEDOT:PSS/PPA Nanocomposite
por: Farea, Mohammed O., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4la38f8uvptvm95nbhppgiiifq