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Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we co...

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Detalles Bibliográficos
Autores principales: O'Donnell, Cian, Gonçalves, J Tiago, Portera-Cailliau, Carlos, Sejnowski, Terrence J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663477/
https://www.ncbi.nlm.nih.gov/pubmed/29019321
http://dx.doi.org/10.7554/eLife.26724