Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex

Cell junctions are scaffolds that integrate mechanical and chemical signaling. We previously showed that a desmosomal cadherin promotes keratinocyte differentiation in an adhesion-independent manner by dampening Epidermal Growth Factor Receptor (EGFR) activity. Here we identify a potential mechanism...

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Detalles Bibliográficos
Autores principales: Najor, Nicole Ann, Fitz, Gillian Nicole, Koetsier, Jennifer Leigh, Godsel, Lisa Marie, Albrecht, Lauren Veronica, Harmon, Robert, Green, Kathleen Janee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663478/
https://www.ncbi.nlm.nih.gov/pubmed/28891468
http://dx.doi.org/10.7554/eLife.22599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663478/
https://www.ncbi.nlm.nih.gov/pubmed/28891468
http://dx.doi.org/10.7554/eLife.22599

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