ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition

ERα phosphorylation at hinge site S294 (pS294) was recently shown to be essential for ER-dependent gene transcription and mediated by an unknown cyclin-dependent kinase (CDK). This study was undertaken to identify the exact CDK pathway mediating pS294 formation, and to determine if this phosphorylat...

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Detalles Bibliográficos
Autores principales: Scott, Gary K., Chu, David, Kaur, Ravneet, Malato, Julia, Rothschild, Daniel E., Frazier, Katya, Eppenberger-Castori, Serenella, Hann, Byron, Park, Ben Ho, Benz, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663526/
https://www.ncbi.nlm.nih.gov/pubmed/29137354
http://dx.doi.org/10.18632/oncotarget.12735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663526/
https://www.ncbi.nlm.nih.gov/pubmed/29137354
http://dx.doi.org/10.18632/oncotarget.12735

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