Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor

Epigenetic regulation of gene expression is an emerging target to treat several human diseases including cancers. In cancers, expressions of many tumor suppressor genes are suppressed by hyper-methylation in their regulatory regions. Herein, we describe a novel carbazole SH-I-14 that decreased the l...

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Detalles Bibliográficos
Autores principales: Kang, Hyo Jin, Yi, Yong Weon, Hou, Shu-Jie, Kim, Hee Jeong, Kong, Yali, Bae, Insoo, Brown, Milton L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663528/
https://www.ncbi.nlm.nih.gov/pubmed/29137356
http://dx.doi.org/10.18632/oncotarget.4054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663528/
https://www.ncbi.nlm.nih.gov/pubmed/29137356
http://dx.doi.org/10.18632/oncotarget.4054

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