LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells

An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E express...

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Autores principales: Yang, Yali, Ren, Mingxin, Song, Chao, Li, Dan, Soomro, Shahid Hussain, Xiong, Yajie, Zhang, Hongfeng, Fu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663582/
https://www.ncbi.nlm.nih.gov/pubmed/29137410
http://dx.doi.org/10.18632/oncotarget.20340
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author Yang, Yali
Ren, Mingxin
Song, Chao
Li, Dan
Soomro, Shahid Hussain
Xiong, Yajie
Zhang, Hongfeng
Fu, Hui
author_facet Yang, Yali
Ren, Mingxin
Song, Chao
Li, Dan
Soomro, Shahid Hussain
Xiong, Yajie
Zhang, Hongfeng
Fu, Hui
author_sort Yang, Yali
collection PubMed
description An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E expression which led to G0/G1 cell cycle arrest and inhibited cell proliferation in glioma cells. LINC00461 suppression also inhibited glioma cell migration and invasion. The function of LINC00461 in glioma cells is partially mediated by MAPK/ERK and PI3K/AKT signaling pathways as down-regulation of LINC00461 expression suppressed ERK1/2 and AKT activities. Moreover, LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes MEF2C and TMEM161B. Taken together, our results demonstrate that LINC00461 is important for glioma progression affecting cell proliferation, migration and invasion via MAPK/ERK, PI3K/AKT, and possibly other signaling pathways.
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spelling pubmed-56635822017-11-13 LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells Yang, Yali Ren, Mingxin Song, Chao Li, Dan Soomro, Shahid Hussain Xiong, Yajie Zhang, Hongfeng Fu, Hui Oncotarget Research Paper An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E expression which led to G0/G1 cell cycle arrest and inhibited cell proliferation in glioma cells. LINC00461 suppression also inhibited glioma cell migration and invasion. The function of LINC00461 in glioma cells is partially mediated by MAPK/ERK and PI3K/AKT signaling pathways as down-regulation of LINC00461 expression suppressed ERK1/2 and AKT activities. Moreover, LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes MEF2C and TMEM161B. Taken together, our results demonstrate that LINC00461 is important for glioma progression affecting cell proliferation, migration and invasion via MAPK/ERK, PI3K/AKT, and possibly other signaling pathways. Impact Journals LLC 2017-08-18 /pmc/articles/PMC5663582/ /pubmed/29137410 http://dx.doi.org/10.18632/oncotarget.20340 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yang, Yali
Ren, Mingxin
Song, Chao
Li, Dan
Soomro, Shahid Hussain
Xiong, Yajie
Zhang, Hongfeng
Fu, Hui
LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
title LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
title_full LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
title_fullStr LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
title_full_unstemmed LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
title_short LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
title_sort linc00461, a long non-coding rna, is important for the proliferation and migration of glioma cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663582/
https://www.ncbi.nlm.nih.gov/pubmed/29137410
http://dx.doi.org/10.18632/oncotarget.20340
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