LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells
An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E express...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663582/ https://www.ncbi.nlm.nih.gov/pubmed/29137410 http://dx.doi.org/10.18632/oncotarget.20340 |
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author | Yang, Yali Ren, Mingxin Song, Chao Li, Dan Soomro, Shahid Hussain Xiong, Yajie Zhang, Hongfeng Fu, Hui |
author_facet | Yang, Yali Ren, Mingxin Song, Chao Li, Dan Soomro, Shahid Hussain Xiong, Yajie Zhang, Hongfeng Fu, Hui |
author_sort | Yang, Yali |
collection | PubMed |
description | An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E expression which led to G0/G1 cell cycle arrest and inhibited cell proliferation in glioma cells. LINC00461 suppression also inhibited glioma cell migration and invasion. The function of LINC00461 in glioma cells is partially mediated by MAPK/ERK and PI3K/AKT signaling pathways as down-regulation of LINC00461 expression suppressed ERK1/2 and AKT activities. Moreover, LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes MEF2C and TMEM161B. Taken together, our results demonstrate that LINC00461 is important for glioma progression affecting cell proliferation, migration and invasion via MAPK/ERK, PI3K/AKT, and possibly other signaling pathways. |
format | Online Article Text |
id | pubmed-5663582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56635822017-11-13 LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells Yang, Yali Ren, Mingxin Song, Chao Li, Dan Soomro, Shahid Hussain Xiong, Yajie Zhang, Hongfeng Fu, Hui Oncotarget Research Paper An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E expression which led to G0/G1 cell cycle arrest and inhibited cell proliferation in glioma cells. LINC00461 suppression also inhibited glioma cell migration and invasion. The function of LINC00461 in glioma cells is partially mediated by MAPK/ERK and PI3K/AKT signaling pathways as down-regulation of LINC00461 expression suppressed ERK1/2 and AKT activities. Moreover, LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes MEF2C and TMEM161B. Taken together, our results demonstrate that LINC00461 is important for glioma progression affecting cell proliferation, migration and invasion via MAPK/ERK, PI3K/AKT, and possibly other signaling pathways. Impact Journals LLC 2017-08-18 /pmc/articles/PMC5663582/ /pubmed/29137410 http://dx.doi.org/10.18632/oncotarget.20340 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yang, Yali Ren, Mingxin Song, Chao Li, Dan Soomro, Shahid Hussain Xiong, Yajie Zhang, Hongfeng Fu, Hui LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells |
title | LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells |
title_full | LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells |
title_fullStr | LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells |
title_full_unstemmed | LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells |
title_short | LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells |
title_sort | linc00461, a long non-coding rna, is important for the proliferation and migration of glioma cells |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663582/ https://www.ncbi.nlm.nih.gov/pubmed/29137410 http://dx.doi.org/10.18632/oncotarget.20340 |
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