Mitochondrial DNA depletion, mitochondrial mutations and high TFAM expression in hepatocellular carcinoma

We investigated the role of mitochondrial genetic alterations in hepatocellular carcinoma by directly comparing the mitochondrial genomes of 86 matched pairs of HCC and non-tumor liver samples. Substitutions in 637 mtDNA sites were detected, comprising 89.80% transitions and 6.60% transversions. For...

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Detalles Bibliográficos
Autores principales: Qiao, Lihua, Ru, Guoqing, Mao, Zhuochao, Wang, Chenghui, Nie, Zhipeng, Li, Qiang, Huang-yang, Yiyi, Zhu, Ling, Liang, Xiaoyang, Yu, Jialing, Jiang, Pingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663603/
https://www.ncbi.nlm.nih.gov/pubmed/29137431
http://dx.doi.org/10.18632/oncotarget.21033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663603/
https://www.ncbi.nlm.nih.gov/pubmed/29137431
http://dx.doi.org/10.18632/oncotarget.21033

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