Tumor-biopsy stratification based on mTOR-pathway activity and functional mutations in the upstream genes PIK3CA and PTEN

The mechanistic target of the rapamycin (mTOR) pathway is frequently activated in human cancers. Our objective was to evaluate relationships between mTOR-pathway activity and functional mutations in the upstream genes PIK3CA and PTEN in solid-tumor biopsies from a broad selection of cancer types. Fo...

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Detalles Bibliográficos
Autores principales: Laes, Jean-François, Sauvage, Sebastien, Ghitti, Gregori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663608/
https://www.ncbi.nlm.nih.gov/pubmed/29137436
http://dx.doi.org/10.18632/oncotarget.21348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663608/
https://www.ncbi.nlm.nih.gov/pubmed/29137436
http://dx.doi.org/10.18632/oncotarget.21348

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