Designing broad-spectrum anti-HIV-1 gRNAs to target patient-derived variants

Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated protein 9 (Cas9), including specific guide RNAs (gRNAs), can excise integrated human immunodeficiency virus type 1 (HIV-1) provirus from host chromosomes. To date, anti-HIV-1 gRNAs have been designed to account for...

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Detalles Bibliográficos
Autores principales: Dampier, Will, Sullivan, Neil T., Chung, Cheng-Han, Mell, Joshua Chang, Nonnemacher, Michael R., Wigdahl, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663707/
https://www.ncbi.nlm.nih.gov/pubmed/29089503
http://dx.doi.org/10.1038/s41598-017-12612-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663707/
https://www.ncbi.nlm.nih.gov/pubmed/29089503
http://dx.doi.org/10.1038/s41598-017-12612-z

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