Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 5–8 million people in Latin America. Although the nitroheterocyclic compound benznidazole has been the front-line drug for several decades, treatment failures are common. Benznidazole is a pro-drug and is bio-activated...

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Detalles Bibliográficos
Autores principales: Campos, Mônica C., Phelan, Jody, Francisco, Amanda F., Taylor, Martin C., Lewis, Michael D., Pain, Arnab, Clark, Taane G., Kelly, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663738/
https://www.ncbi.nlm.nih.gov/pubmed/29089615
http://dx.doi.org/10.1038/s41598-017-14986-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663738/
https://www.ncbi.nlm.nih.gov/pubmed/29089615
http://dx.doi.org/10.1038/s41598-017-14986-6

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