Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient

We report here the sequence and functional characterization of a recombinantly expressed autoantibody (mAb 131) previously isolated from a myasthenia gravis patient by immortalization of thymic B cells using Epstein-Barr virus and TLR9 activation. The antibody is characterized by a high degree of so...

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Detalles Bibliográficos
Autores principales: Saxena, Abhishek, Stevens, Jo, Cetin, Hakan, Koneczny, Inga, Webster, Richard, Lazaridis, Konstantinos, Tzartos, Socrates, Vrolix, Kathleen, Nogales-Gadea, Gisela, Machiels, Barbie, Molenaar, Peter C., Damoiseaux, Jan, De Baets, Marc H., Simon-Keller, Katja, Marx, Alexander, Vincent, Angela, Losen, Mario, Martinez-Martinez, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663942/
https://www.ncbi.nlm.nih.gov/pubmed/29089519
http://dx.doi.org/10.1038/s41598-017-14350-8

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